Sentinel (Milbemycin Oxime / Lufenuron)

Only Available By Prescription

Top brand choice

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Milbemycin oxime with Lufenuron is used in the prevention of heartworm disease and in the control of hookworm, roundworm and whipworm. When combined with Lufenuron it is also used to control fleas by preventing the development of flea eggs. The medication does not kill adult fleas.
Brown extra small dogs intl equivalent is Pink.

N.B. We sell U.K versions of the products listed below. Sentinel is known as Program Plus in the U.K but contains the same active ingredient -milbemycin oxime + lufenuron

International Product: Program Plus is not a flavored tablet


Milbemycin oxime with Lufenuron is indicated for use in dogs and puppies four weeks of age and older, and two pounds body weight or greater. The usual dose of milbemycin oxime with Lufenuron for dogs 2-10 pounds is 2.3mg/46mg, 11-25 pounds is 5.75mg/115mg, 26-50 pounds is 11.5mg/230mg and 51-100 pounds is 23mg/460mg given once a month year round. An alternate treatment is to give this medication once a month during the mosquito season and also one month after the season ends.


Milbemycin oxime/lufeneron


This medication should not be used in animals allergic to it. The pet should be tested for heartworm disease before starting this medication. If the pet has been off heartworm preventative for 6 months or more, retest in 6 months since microfilaria, that take 6 months to mature, will cause a positive test result. Because humans can contract hookworm and roundworm from animals it is important to maintain good personal hygiene. It is also important to eliminate fleas on the pet and in the household and to not feed the pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.