Nexgard (Afoxolaner)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


NexGard is a beef-flavored chewable tablet medication for dogs that eliminates fleas, black-legged tick, American dog tick, Lone Star tick and Brown dog tick. With Nexgard you are giving your dog the same flea and tick medication that veterinarians choose to give their own dogs. Its approved for dogs aged 8 weeks and older and weighing at least 4 lbs.

The active ingredient in NexGard is Afoxolaner (1-Naphthalenecarboxamide, 4-[5- [3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl).


NexGard comes in small, medium, large, and extra-large dog size options and should be administered once a month and based on the following guideline: 

  • Small Dogs (4.0 to 10.0 lbs.) - 11.3 mg / One chewable
  • Medium Dogs (10.1 to 24.0 lbs.) - 28.3 mg / One chewable
  • Large Dogs (1 to 60.0 lbs.) - 68 mg / One chewable
  • Extra Large Dogs (60.1 to 121.0 lbs.) - 136 mg / One chewable 

For dogs over 121.0 lbs. administer the appropriate combination of NexGard chewables. 

  • NexGard can be administered with or without food
  • Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused
  • If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, re-dose with another full dose
  • If a dose is missed, administer NexGard and resume a monthly dosing schedule.
  • Treatment with NexGard may begin at any time of the year
  • In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption


The active ingredient in NexGard is Afoxolaner (1-Naphthalenecarboxamide, 4-[5- [3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl).


  • Not for use in humans
  • Keep this and all drugs out of the reach of children
  • In case of accidental ingestion, contact a physician immediately
  • The safe use of NexGard in breeding, pregnant, or lactating dogs has not been evaluated
  • Use with caution in dogs with a history of seizures

Side Effects

Vomiting, possibly with blood (incidence approx. 4.1%), dry or flaky skin (3.1%), diarrhea (possibly with blood) (3.1%), lethargy (1.7%), anorexia (1.2%).

This information is for informational purposes only. It is not to be a substitute for the diagnosis, treatment, or professional advice of a veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition or the use of a particular medication.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for your pet. See your veterinarian for medical advice and treatment for your pet if you have any concerns.