Heartgard Plus (Ivermectin / Pyrantel)

Only Available By Prescription

Top brand choice


Top Generic choice

What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Heartgard Plus is a chewable tablet medication that is 100% effective for the prevention of heartworms in dogs, and also prevents roundworms and hookworms. It is safe for use with dogs that are 6 weeks of age or older, and can be administered to pregnant or nursing females, stud dogs, collies, and dogs with collie genetics.

The active ingredients in Heartgard Plus are Ivermectin and Pyrantel.


Heartgard Plus should be administered once a month and based on the following guideline: 

  • dogs up to 25 pounds: 68 mcg / 57 mg
  • dogs 26-50 pounds: 136 mcg /114 mg
  • dogs 51-100 pounds: 272 mcg / 227 mg
  • dogs over 100 pounds will be given a combination of tablets using the above dosage guideline 
  • Remove only one chewable at a time from the foil-backed blister card
  • Return the card with the remaining chewables to its box to protect the product from light
  • Care should be taken that the dog consumes the complete dose 

As an alternate to year-round dosing, this medication can be given during the mosquito season and then for one month after the season ends.




  • This product is for use only with dogs, and only those 6 weeks of age or older
  • All dogs should be tested for existing heartworm infection before starting treatment with Heartgard Plus
  • Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heartgard Plus
  • The product can usually be offered to the dog by hand
  • Alternatively, it may be added intact to a small amount of dog food
  • Chewables may be broken into pieces and fed to dogs that normally swallow treats whole

Side Effects

It is reported that side effects resulting from the use of Heartgard Plus for dogs are rare.

This information is for informational purposes only. It is not to be a substitute for the diagnosis, treatment, or professional advice of a veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition or the use of a particular medication.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for your pet. See your veterinarian for medical advice and treatment for your pet if you have any concerns.