How Long Does it Take Frontline Plus To Work?

How Long Does it Take Frontline Plus To Work?


Frontline Plus will get rid of all fleas within 18 hours of contact with your pet and will kill all ticks within 48 hours after coming in contact with your pet. Frontline Plus covers your pet’s whole body within 24 hours of application. It spreads on your pet’s body through a process called translocation. In translocation, Frontline Plus is accumulated inside the oil glands after which it gradually flows out and coats your pet’s fur over the next 30 days.

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Frontline Plus will kill fleas and ticks as soon as they come in contact with the Frontline-coated fur. Fleas and ticks don't need to bite your pet in order for Frontline Plus to work but will die simply on contact. It is possible that you see more fleas on your pet after using Frontline Plus. However, this is a sign that the medication is working. Frontline makes fleas hyperactive before killing them and attracts them to the top of the hair coat, making them easier to spot.     

More In Depth Details

Frontline Plus is the most effective, fast-acting, and easy-to-use medication available to kill ticks and fleas in dogs and cats. However, the main question is; how long does Frontline Plus take to work? Is it worth buying?

Frontline Plus can get rid of all fleas within 12 hours along with all lice and ticks within 48 hours. It also works against the lone star tick, brown dog tick, and the American dog tick and also helps to prevent Lyme disease by killing the deer tick.

Signs that your pet has ticks or fleas

  • There is a tick in your house

If you spot a tick on the carpet, bed, or on the floor, it is highly likely that your pet brought it inside the house. Do not ignore the tick and examine your pet further. If your pet does have ticks, apply Frontline Plus immediately to get rid of the pests.

  • Your pet has a fever

Your pet can develop a mild or high-grade fever if it is bitten by a tick. Symptoms of a fever include loss of appetite, unusual panting, weakness, and shivering. The fever may last for only 24 hours but can also continue for several weeks. It is possible that your dog has developed a fever because of some other sickness, but it is better to examine your dog for ticks

  • Unexplained scabs

A tick bite can result in your dog or cat constantly nipping or licking the bite site. If you spot a scab on your pet’s body or notice this behavior, check your pet further for any ticks.

  • Your pet shakes its head a lot

If your dog or cat is constantly shaking its head, it is possible that there is a tick in its ear canal. Ticks usually look for warm, damp places to hide and may crawl inside your dog’s groin, ears, or under his front legs. It is better to use a flashlight to look inside your pet’s ear for ticks if you notice it shaking its head more than usual.

  • You feel small bumps on your pet’s body

One of the first signs that tell you about ticks is small bumps on your dog’s skin. If you feel a bump while petting your dog, do not ignore it and examine your dog immediately for ticks.

How does Frontline Plus work?

Frontline Plus consists of two main chemicals, Fipronil and S-Methoprene. Fipronil works by damaging the nervous system of fleas and ticks while S-Methoprene helps prevent flea eggs from hatching. It also contains inert chemicals which bind these two chemicals together. Frontline plus should be applied once every month to help kill all fleas and ticks.

As Fipronil is fat-soluble, it collects inside the oil glands found on an animal’s skin. Once Fipronil is absorbed by the animal’s skin, it flows out of the oil glands slowly, consequently coating the fur of the animal. Now, when a flea or tick comes in contact with the Fipronil-covered fur, its nerve cells are damaged because of the poison. Fipronil particularly affects receptors that receive signals that keep the nervous system of ticks and fleas relaxed. Because of the insecticide, the nervous system becomes hyperactive, and the ticks die within 30 minutes.

Ticks fall off before they can lay eggs; however, a female flea can lay almost 50 eggs in a day. Frontline Plus does not contain high enough concentrations of Fipronil to get rid of all the fleas; hence S-Methoprene comes into play. S-Methoprene does not harm your pet but works by seeping into the flea eggs. It acts as a hormone and prevents the flea from reaching its next developmental stage, thus killing it. 

How to properly apply Frontline Plus

Frontline Plus for dogs should only be used for dogs and puppies older than 8 weeks. If your dog is up to 22 lbs., 0.67 ml applicators of Frontline Plus should be used. If your dog weighs between 23 and 44 lbs., 1.34 ml applicators should be used. For dogs weighing 45-88 lbs., 2.68 ml applicators should be used, and 4.02 ml applicators should be used for dogs weighing 89-132 lbs. Frontline Plus for cats should only be used on cats and kittens older than 8 weeks, using the 0.5 ml applicators.

Find an area between the shoulder blades, preferably one that cannot be licked and apply the applicator on the animal’s skin. Use Frontline Plus only once a month and let the medicine dry after application before bathing your pet or letting it go for a swim.  

Purchase Frontline Plus for less than your local Drugstore or Pharmacy. Compare prices by clicking here.

To save even more use coupon code TPSBlogFLP at checkout to save an additional 20%!

Side effects

Your pet will not experience any severe side effects if it is healthy, is not allergic to any of the main ingredients, and is given the correct dosage of Frontline Plus monthly. However, visit your veterinarian immediately if you notice any of the following side effects in your pet:

  • Lethargy
  • Excessive salivation
  • Vomiting or severe diarrhea
  • Swelling of the face, lips, or tongue
  • Uncoordinated movements
  • Coma
  • Rash or hives
  • Seizures