Eli Lilly

Chemical Name: PIOGLITAZONE (pye-oh-GLI-ta-zone)

ACTOS is a prescription medication used in conjunction with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. It can also sometimes be used in combination with insulin or other medications, but it is not for treating type 1 diabetes. Additionally, ACTOS is not a substitute for cholesterol medication.

It is vital to take ACTOS exactly as prescribed by your doctor. Do not take for longer than recommended. Taking this medication for longer than 1 year (12 months) may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

ACTOS is generally taken once daily. You may take ACTOS with or without food. Ask your doctor how to adjust your ACTOS dose if needed. Do not change your medication dose or schedule without your medical advice.

Patients should check their blood sugar often, and you may need other blood tests at your doctor's office. Visit your doctor regularly. Use ACTOS regularly to get the most benefit.

When taking ACTOS with insulin or other diabetes medications, low blood sugar may occur. Talk to your doctor if low blood sugar is a problem for you. When taking ACTOS with insulin, the chance of fluid retention is increased, this may lead to or worsen heart failure. You should tell your doctor immediately if you develop fluid retention, especially in the ankles or legs.

Do not take ACTOS if you:

• are allergic to ACTOS or any of its ingredients
• are a patient with heart failure or heart disease
• have active bladder cancer
• if you are in a state of diabetic ketoacidosis
• have liver disease
• are pregnant or breastfeeding
• have fluid retention

ACTOS is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

The most common side effects of these products include:

• cold-like symptoms including headache, sinus infection, muscle pain, and sore throat
• shakiness
• dizziness
• rapid heartbeat
• sweating
• confusion
• blurred vision
• numbness or tingling of the mouth
• weakness or tiredness
• pale color
• sudden hunger

The above noted side effects may not require medical attention and may slowly decrease over time as your body adjusts to the medication. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.